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Performance of lung ultrasonography in children with community-acquired pneumonia

Conclusion: US can be considered a useful means of diagnosing CAP in children admitted to an Emergency Department with a lower respiratory tract infection, although its usefulness in identifying the type...

Sat 19 04 2014 Bibliographie

Inflammatory cytokines in pulmonary hypertension

Pulmonary hypertension is an "umbrella term" used for a spectrum of entities resulting in an elevation of the pulmonary arterial pressure. Clinical symptoms include dyspnea and fatigue which in the...

Sat 19 04 2014 Bibliographie

Classification of the idiopathic interstitial pneumonias.

Authors: Corrin B PMID: 24735039 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)

Sat 19 04 2014 Bibliographie

Effect of inhaled corticosteroids on systemic inflammation in asthma.

Related Articles Effect of inhaled corticosteroids on systemic inflammation in asthma. ...

Sat 19 04 2014 Bibliographie

Daily versus intermittent inhaled corticosteroid treatment for mild persistent asthma.

Related Articles Daily versus intermittent inhaled corticosteroid treatment for mild persistent asthma. ...

Sat 19 04 2014 Bibliographie

Assessment of various second-line medications in addition to inhaled corticosteroid…

Related Articles Assessment of various second-line medications in addition to inhaled corticosteroid in asthmatic patients - A randomized controlled trial. ...

Sat 19 04 2014 Bibliographie

Treating severe allergic asthma with anti-IgE monoclonal antibody (omalizumab): a…

Related Articles Increased asthma severity is not only associated with enhanced recurrent hospitalization and mortality but also with higher social costs.Several cases of asthma are atopic in nature, with the trigger...

Fri 18 04 2014 Bibliographie

Fungal allergy in asthma-state of the art and research needs.

Related Articles Sensitization to fungi and long term or uncontrolled fungal infection are associated with poor control of asthma, the likelihood of more severe disease and complications such as bronchiectasis...

Fri 18 04 2014 Bibliographie

Noninvasive ventilation in acute asthma.

Related Articles Noninvasive ventilation (NIV) has well-recognized benefits in acute exacerbation of chronic obstructive pulmonary disease and pulmonary edema. Its utilization in acute asthma, however, remains controversial. In this review,...

Fri 18 04 2014 Bibliographie

Immediate Anti-Inflammatory Effects of Inhaled Budesonide in Patients with Asthma.

Related Articles Immediate Anti-Inflammatory Effects of Inhaled Budesonide in Patients with Asthma. ...

Fri 18 04 2014 Bibliographie

Official american thoracic society technical standards: spirometry in the occupational…

Related Articles Official american thoracic society technical standards: spirometry in the occupational setting. ...

Fri 18 04 2014 Bibliographie

Respiratory Reviews in Asthma 2013.

Related Articles Respiratory Reviews in Asthma 2013. ...

Fri 18 04 2014 Bibliographie

Electronic cigarettes: navigating the vapor.

Related Articles Electronic cigarettes (e-Cigarettes) are novel nicotine delivery systems that have the potential to drastically change the landscape of nicotine addiction and tobacco use. Their increasing popularity has raised concerns...

Fri 18 04 2014 Bibliographie

Implications of cytokine genes in allergic asthma.

Related Articles Implications of cytokine genes in allergic asthma. ...

Fri 18 04 2014 Bibliographie

A Consensus Parameter for the Evaluation and Management of Angioedema…

Related Articles A Consensus Parameter for the Evaluation and Management of Angioedema in the Emergency Department. ...

Fri 18 04 2014 Bibliographie

Sublingual immunotherapy: World Allergy Organization position paper 2013 update.

Related Articles We have prepared this document, "Sublingual Immunotherapy: World Allergy Organization Position Paper 2013 Update", according to the evidence-based criteria, revising and updating chapters of the originally published paper, "Sublingual...

Thu 17 04 2014 Bibliographie

A retrospective review of antimicrobial prescribing and infection prevalence in…

Related Articles Hospice patients are highly susceptible to infections of the urinary and respiratory tract.The use of antimicrobials for symptom control should be considered against the burden of treatment for the...

Thu 17 04 2014 Bibliographie

Long-term adherence to a 5 day antibiotic course guideline for…

OBJECTIVES: To determine long-term adherence to a 5 day antibiotic course guideline for treating intensive care unit (ICU)-acquired Gram-negative bacteria (GNB) infections. METHODS: Descriptive analysis of patient-level data on all GNB-active...

Thu 17 04 2014 Bibliographie

Prevention and control of haemophilus influenzae type b disease: recommendations…

Related Articles   This report compiles and summarizes all recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) regarding prevention and control of Haemophilus influenzae type b (Hib) disease in the United...

Thu 17 04 2014 Bibliographie

Endoscopic treatment of native lung hyperinflation using endobronchial valves in…

ConclusionsTreating NLH with IBV endobronchial valves leads to clinical improvement in the majority of patients, and the treatment has an acceptable safety. (Source: The Clinical Respiratory Journal)

Wed 16 04 2014 Bibliographie

Can cholesterol be used to distinguish pleural exudates from transudates?…

Conclusions: Both pleural cholesterol level and the P/S cholesterol ratio are helpful for the diagnosis of pleural exudates. Nevertheless, the results of pleural cholesterol assays should be interpreted in parallel with...

Wed 16 04 2014 Bibliographie

Inflammation and infections in asthma

Abstract Asthma is driven by an inflammatory response against normally harmless environmental anorganic and organic compounds in the respiratory tract. The inflammation is characterized by eosinophilia, goblet cell hyperplasia, bronchial hyperresponsiveness...

Wed 16 04 2014 Bibliographie

Low Load / High Repetition Elastic Band Resistance Training in…

ConclusionRT can increase functional capacity and muscular function but not cycle endurance capacity and HRQOL in patients with moderate to severe COPD (Source: The Clinical Respiratory Journal)

Wed 16 04 2014 Bibliographie

Will SUMMIT reach the peak in COPD?

Introduction The Study to Understand Mortality and Morbidity in COPD (SUMMIT) is a randomised controlled trial conducted in patients with COPD and comorbid cardiovascular disease, designed to assess the ‘impact...

Wed 16 04 2014 Bibliographie

COPD and IPF: it's all about regulation and balance

The dominant theory of Hippocrates was that of the four humours—that when the four humours were in balance health prevailed. Therefore, the main goal of the medical therapy was to...

Wed 16 04 2014 Bibliographie

Innate lymphoid cells and asthma

Asthma is a complex and heterogeneous disease with several phenotypes, including an allergic asthma phenotype characterized by TH2 cytokine production and associated with allergen sensitization and adaptive immunity. Asthma also...

Wed 16 04 2014 Bibliographie

Recommendations for live viral and bacterial vaccines in immunodeficient patients and…

The present uncertainty of which live viral or bacterial vaccines can be given to immunodeficient patients and the growing neglect of societal adherence to routine immunizations has prompted the Medical...

Wed 16 04 2014 Bibliographie

Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory…

Background: Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms.Objective: This study aimed to identify and validate a sputum gene expression signature that discriminates asthma inflammatory...

Wed 16 04 2014 Bibliographie

Advances in basic and clinical immunology in 2013

A significant number of contributions to our understanding of primary immunodeficiencies (PIDs) in pathogenesis, diagnosis, and treatment were published in the Journal in 2013. For example, deficiency of mast cell...

Wed 16 04 2014 Bibliographie

The challenge of treating preschool wheezing episodes: The need for evidence-based…

Young children with intermittent wheezing have substantial disease morbidity, particularly related to acute exacerbations. In the June 2013 issue of the Journal, we presented the results of post hoc analyses...

Wed 16 04 2014 Bibliographie

A 2-year randomised placebo-controlled trial of doxycycline for lymphangioleiomyomatosis

Lymphangioleiomyomatosis (LAM) is characterised by lung cysts and airflow obstruction. Matrix metalloproteinases have been implicated in lung destruction in LAM. We performed a randomised, double-blind trial, comparing the matrix metalloproteinases...

Tue 15 04 2014 Bibliographie

Real-life use of inhaled corticosteroids in COPD patients versus the…

To the Editor: Clinical trials in chronic obstructive pulmonary disease (COPD) patients have shown that the long-term use of inhaled corticosteroids ...

Tue 15 04 2014 Bibliographie

Classification and pharmacological treatment of preschool wheezing: changes since 2008

Since the publication of the European Respiratory Society Task Force report in 2008, significant new evidence has become available on the classification and management of preschool wheezing disorders. In this...

Tue 15 04 2014 Bibliographie

Measurement of FEF25-75% and FEF75% does not contribute to clinical…

The aim of this study was to determine the added value of measuring the forced expiratory flow at 25–75% of forced vital capacity (FVC) (FEF25–75%) and flow when 75% of...

Tue 15 04 2014 Bibliographie

COPD and microalbuminuria: a 12-year follow-up study

Chronic obstructive pulmonary disease (COPD), low lung function independent of diagnosis and markers of inflammation are all associated with increased morbidity and mortality. Microalbuminuria, reflecting endothelial dysfunction, could be a...

Tue 15 04 2014 Bibliographie

COPD assessment: I, II, III, IV and/or A, B, C,…

In 2001 the Global Initiative for Chronic Obstructive Lung Disease (GOLD) committee published its first consensus report. At that time the authors suggested that the assessment of chronic ...

Tue 15 04 2014 Bibliographie

Tuberculosis: clinical trials and new drug regimens

Purpose of reviewRecent advances in the development of new drugs and regimens provide hope that well tolerated, effective, and shorter-duration treatments for tuberculosis (TB) will become available. This review covers...

Sat 12 04 2014 Bibliographie

Community-acquired pneumonia

Purpose of reviewThis review examines the epidemiology, diagnosis, prognosis, treatment and prevention of community-acquired pneumonia (CAP) in adults. Recent findingsCAP is a significant cause of morbidity and mortality. Streptococcus pneumoniae is...

Sat 12 04 2014 Bibliographie

Accueil
L'essentiel de la littérature réçente en Pneumologie

In this heading we propose you a review of the literature through a selection of abstracts of recent original articles.
we will try to keep you informed about the last news on Pulmonology. We provide you only the summary of the article and the corresponding link, to reach the article in full text you must be registered with the corresponding review.

Click here to consult the list of the available free medical journals in lung diseases.


Quantitative computed tomography imaging of interstitial lung diseases. Print E-mail
Thursday, 05 September 2013 08:29
Related Articles

High-resolution chest computed tomography (HRCT) is essential in the characterization of interstitial lung disease. The HRCT features of some diseases can be diagnostic. Longitudinal monitoring with HRCT can assess progression of interstitial lung disease; however, subtle changes in the volume and character of abnormalities can be difficult to assess. Accuracy of diagnosis can be dependent on expertise and experience of the radiologist, pathologist, or clinician. Quantitative analysis of thoracic HRCT has the potential to determine the extent of disease reproducibly, classify the types of abnormalities, and automate the diagnostic process.

MATERIALS AND METHODS: Novel software that utilizes histogram signatures to characterize pulmonary parenchyma was used to analyze chest HRCT data, including retrospective processing of clinical CT scans and research data from the Lung Tissue Research Consortium. Additional information including physiological, pathologic, and semiquantitative radiologist assessment was available to allow comparison of quantitative results, with visual estimates of the disease, physiological parameters, and measures of disease outcome.

RESULTS: Quantitative analysis results were provided in regional volumetric quantities for statistical analysis and a graphical representation. These results suggest that quantitative HRCT analysis can serve as a biomarker with physiological, pathologic, and prognostic significance.

CONCLUSIONS: It is likely that quantitative analysis of HRCT can be used in clinical practice as a means to aid in identifying a probable diagnosis, stratifying prognosis in early disease, and consistently determining progression of the disease or response to therapy. Further optimization of quantitative techniques and longitudinal analysis of well-characterized subjects would be helpful in validating these methods.

Read more...
 
Pulmonary rehabilitation in patients with idiopathic pulmonary fibrosis - a review. Print E-mail
Thursday, 05 September 2013 08:29
Related Articles

Among the various types of interstitial lung diseases, idiopathic pulmonary fibrosis (IPF) is the most common disorder and has a poor prognosis and a limited response to pharmacological treatment. In patients with IPF, functional exercise tolerance and quality of life have been shown to be significantly decreased. Current IPF guidelines suggest only a weak recommendation for pulmonary rehabilitation (PR). However, PR is regarded as a reasonable choice for the majority of patients with IPF.

This review will summarize all of the available studies that have investigated the effects of PR in patients with IPF so far. Although only a small number of studies have been published to date, most studies have found significant short-term improvements in functional exercise capacity, quality of life, and level of perceived dyspnea. Long-term improvements or maintenance strategies of PR in IPF patients have not been adequately investigated yet. Up to now there is still no sufficient evidence for the recommendation of PR in IPF. However, physical training seems to be the major component of all PR programs. The current review will discuss potential exercise training regimens for patients with IPF and suggest additional useful modalities of a specific multidisciplinary PR program for IPF patients.

Based on the current literature and our own experience, this article will try to highlight the importance of PR as an additional, beneficial therapeutic option for patients with IPF. © 2013 S. Karger AG, Basel.

Read more...
 
The role of infection in the pathogenesis of idiopathic pulmonary fibrosis. Print E-mail
Wednesday, 04 September 2013 07:20
Related Articles

Idiopathic pulmonary fibrosis (IPF) is a progressive, and invariably fatal, condition that is believed to arise in genetically susceptible individuals as a consequence of an aberrant wound-healing response following repetitive alveolar injury.

The exact triggers, which initiate the fibrotic process, remain unknown. Infectious agents, including both viruses and bacteria, have the capacity to cause alveolar-epithelial cell injury and apoptosis.

Relatively few studies have examined the role of infection in IPF. Those that have, point to viruses playing a key role as cofactors in the initiation and progression of IPF. There is also some evidence to suggest that viral infection may be responsible for a proportion of acute exacerbations of IPF. The role played by bacteria in the pathogenesis of IPF is less clear cut. Studies from other respiratory diseases suggest that alterations in the lung microbiome are associated with disease and that these changes influence disease behaviour. Emerging molecular microbiological techniques are making the study of microbial communities in the lung easier. It is hoped that by combining such techniques with the careful longitudinal phenotyping of patients with IPF, it will be possible to elucidate the role played by bacteria and viruses in the pathogenesis of the disease.

If infection plays a causal role in IPF then it is possible that therapeutic strategies, utilising currently available antiviral or antibiotic drugs, may be effective in modifying the course of this devastating condition.

Read more...
 
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