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L'essentiel de la littérature réçente en Pneumologie

In this heading we propose you a review of the literature through a selection of abstracts of recent original articles.
we will try to keep you informed about the last news on Pulmonology. We provide you only the summary of the article and the corresponding link, to reach the article in full text you must be registered with the corresponding review.

Click here to consult the list of the available free medical journals in lung diseases.


Non-invasive mechanical ventilation and mortality in elderly immunocompromised patients hospitalized with pneumonia: a retrospective cohort study Print E-mail
Thursday, 30 January 2014 08:34

Mortality after pneumonia in immunocompromised patients is higher than for immunocompetent patients. The use of non-invasive mechanical ventilation for patients with severe pneumonia may provide beneficial outcomes while circumventing potential complications associated with invasive mechanical ventilation. The aim of our study was to determine if the use of non-invasive mechanical ventilation in elderly immunocompromised patients with pneumonia is associated with higher all-cause mortality.

Methods : In this retrospective cohort study, data were obtained from the Department of Veterans Affairs administrative databases. We included veterans age >=65 years who were immunocompromised and hospitalized due to pneumonia. Multilevel logistic regression analysis was used to determine the relationship between the use of invasive versus non-invasive mechanical ventilation and 30-day and 90-day mortality.

Results : Of 1,946 patients in our cohort, 717 received non-invasive mechanical ventilation and 1,229 received invasive mechanical ventilation. There was no significant association between all-cause 30-day mortality and non-invasive versus invasive mechanical ventilation in our adjusted model (odds ratio (OR) 0.85, 95% confidence interval (CI) 0.66-1.10). However, those patients who received non-invasive mechanical ventilation had decreased 90-day mortality (OR 0.66, 95% CI 0.52-0.84). Additionally, receipt of guideline-concordant antibiotics in our immunocompromised cohort was significantly associated with decreased odds of 30-day mortality (OR 0.31, 95% CI 0.24-0.39) and 90-day mortality (OR 0.41, 95% CI 0.31-0.53).

Conclusions : Our findings suggest that physicians should consider the use of non-invasive mechanical ventilation, when appropriate, for elderly immunocompromised patients hospitalized with pneumonia.

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Screening for Middle East Respiratory Syndrome Coronavirus Infection in Hospital patients and their Health care Worker and Family Contacts: a prospective descriptive study Print E-mail
Thursday, 30 January 2014 08:34

The Saudi Arabian Ministry of Health implemented a proactive surveillance program for MERS coronavirus (MERS-CoV). We report MERS-CoV data from 5,065 KSA individuals who were screened for MERS-CoV over a 12 month period.

Methods : From October 1st, 2012 to September 30th 2013 demographic and clinical data was prospectively collected from all laboratory forms received at the Saudi Arabian Virology reference laboratory. Data were analysed by referral type, age, gender, and MERS-CoV RT-PCR test results.

Findings : 5,065 individuals were screened for MER-CoV: Hospitalized patients with suspected MERS-CoV infection (n=2,908, 57.4%), Health care worker (HCW) contacts (n=1695; 33.5%), and family contacts (FC) of laboratory confirmed MERS cases (n=462; 9.1%). 11% of persons tested were children (<17years old). There were 106 cases (99 adults and 7 children) of MERS-CoV infection detected during the 12 month period (106/5065, 2% case detection rate). Of 106 cases, 44 were females (5 children and 39 adults), and 62 were males (2 children and 60 adults). Of the 99 adults with MERS-CoV infection, 70 were hospitalised patients, 19 were HCW contacts, and 10 family contacts. There was no significant rises in MERS-CoV detection rates over the 12 month period, 2.6% (19/731) in July 2013, 1.7% (19/1100) in August and 1.69% (21/1238) in September 2013. Male patients had a significantly higher MERS-CoV infection rate (62/2318, 2.6%) than females (44/2747, 1.7%) (P=0.013).

Interpretation : MERS-CoV rates remain at low levels with no significant increase over time. Proactive surveillance for MERS-CoV in newly diagnosed patients and their contacts will continue.

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How long should we maintain long‐term azithromycin treatment in cystic fibrosis patients? Print E-mail
Thursday, 30 January 2014 08:34

No abstract is available for this article.

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